Root DROID X

[Natey2]

Are there any core apps that currently don't work once rooted?

Not a core app, but apps like "Good" may not connect to corporate servers if the device is rooted: the Good servers can be configured by corporate sysadmins to disallow connections from rooted devices. Some sysadmins consider jailbroken or rooted devices a threat/security compromise.
http://play.google.com/store/apps/details?id=com.good.android.gfe

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