As a first smart phone the TB will absolutely blow you away. I can't really give too many in depth tips because, well, there are simply too many tips to give...haha. but in all seriousness, there are many in depth guides and tips and tricks articles for android floating around the net. Just Google android tips and you'll be fine.
The one tip I will give is to make sure you hit the menu button A LOT. Literally, every time you see something new on your screen, hit the menu button and see if there are any hidden menus and settings to be found. Nearly every app has its own settings menu and you'll be surprised at how much customization you can do. Basically, just take your time and explore every facet of your phone. It might take a few weeks or even months to learn where everything is and what it does but in the end its well worth it.
Also, I recommend leaving your phone stock until you learn all of the ins and outs. The TB will most likely be rooted fairly quickly and the dev community will make short order of overclocking the beast and compiling custom roms. Many, more experienced android users (including myself) will jump on the root bandwagon pretty quickly. In fact, I think many of us are getting the TB rather than waiting for the bionic specifically for that reason due to the un-encrypted bootloader. Read all that you can about rooting and what it can do for you. It may be something you want to do in the future, but for now, just enjoy what will be one of the most powerful stock mobile experiences around. Best of luck!!