Yes, you lose the sense widgets, but...is it a big loss? Launcherpro has a plus version now with its own widgets similar to sense, but I believe its 2.99 which is still worth it to me. If you download beautiful widgets (2.79?) It has the clock and weather widget with the unlock effect along with all the other widgets that you may need.
There is also a handy add on to any home called Quicksettings (free) that runs when you hold your search button down and pulls up all the settings you would need; brightness, volume, gps, wifi, bluetooth. I found that to be handy if your also interested.