Sorry to confirm the bad news, but it won't work. The Incredible S is a GSM device, while the Incredible 2 is a CDMA device with GSM capabilities. While the hardware and much of the software are similar, there are important differences in both that make flashing a ROM made for one impossible on the other. So, a ROM made for the Incredible S won't have the proper files and software needed to run the Incredible 2.
A pretty good rule of thumb for flashing ROMs is that if it isn't made for your specific device, don't flash it. If you do, you'll probably be in for one heck of a headache.