Do a battery pull (not just a reboot).
If problem persists "grit your teeth" and do a Factory Reset. These have gotten pretty painless lately by following these simple steps: 1. Make sure Backup and Restore are checked in the Privacy setting. 2. When going through the setup after the reset, turn on wifi as soon as you can (assuming it is available). 3. After you have entered your Gmail account info, you will be presented with a screen that has two check boxes. Basically they are "Do you want Google to backup and restore this phone”. Make sure you check both of those. Your apps will then automatically reinstall (paid and free). Set the phone aside for a minute or two and let the apps download and install. 3. If rooted, use an app such as titanium backup to restore data only to select apps such as Tapatalk and you will not have to re-enter all your login information. I do this for 3-4 apps (Tapatalk, SPB Shell, etc.).
I've been flashing new roms/updates about once per day lately and I can be up and running with all my apps and settings back in place in less than 20 minutes. It's pretty painless now.
NOTE: I learn this morning that not everyone has been as lucky as I with the automatic re-installs. So good luck if you end up having to go that route.