I'm running Liberty .07 with ADW.
My homescreen dock has five icons. The middle icon (app drawer launcher) and the left most icon (dialer) lose functionality (nothing happens when I click them) after the home screen rotates. I have to manually long press on each and reassign their tasks, after which they work, until home screen orientation changes again.
If it's relevant, all of my homescreen icons (the dock and the several others along the right edge) have cutoms images assigned to them.