I also use titanium frequently, I only restore the apps on a fresh install, no data, except for my folder organizer app because there's no way I'm setting that back up again. Did you try wiping dalvik and cache in recovery by chance?
I would factory default, restore contacts and SMS, and add nothing for a day or two... if the battery drain continues it's probably a bad handset, if it stops then an app or something an app did is causing the issue, so probably don't want to restore apps.
I did exactly this. Wiped everything last night. I only re-installed about 5 apps (keyboard, alarm clock, battery monitor, titanium backup) So far since last night it's been much better. no battery drain, no annoying flickering of widgets, no service issues. If I get through the day and it's still being good, I'll start reinstalling a few apps at a time. It will take me a few days to get re setup, but hopefully it'll fix my issues. Thanks for all the suggestions, everyone. I'll let you know how it goes.
Well day 2 after the wipe, and it's working better than ever. I recovered a dozen more apps last night, and it's still working well. after 20 hours of being on battery last night I was @ 50%. Of course I don't have facebook or email loaded back up yet, but still it seems to be back to normal and then some. Still don't know what caused it, but it looks like I have it fixed. Thanks for the help everyone.
Let me know how the facebook thing goes. My daughter's phone works great until she installs facebook and that is when she gets major battery drain. Sadly, she just gets rid of facebook. :)