Ok I am wondering if anyone else has tried this or knows the answer.
On my Incredible, I use launcherpro beta and the phone seems to be much faster. When I used the sense homescreen, sometimes when i hit the home button i would run into an HTC logo while it loaded.
Other than that i just find launcher pro to be much MUCH speedier.
for those who say it defeats the purpose of getting a sense phone, it does not. There is so much more to sense phones then the homescreens and widgets.