This is the only thing I worry about with this new update when it its me and Titanium Backup. I like TBU, but if you can't get root, then it is worthless until you can. So I have been using Astro File Manager to back up all my apps just in case until I can get root again.
Is there a better way? I mean, I'm sure there will be a way to root (or is) 2.2.1. I really haven't looked yet. I'm waiting to take the update personally and then deal with it then.