LTE will hurt. My tbolt with the 2750 battery could get a day and a half on 3g but only a day on LTE. The battery is over year old now, but I still get over a day on 3g and can't get though a day on LTE unless I am barely on it.
I understand it has improved with newer processors, but we still have like 8 different radios in these things. Until 10 years from now when we shut down all the old towers, battery life will suffer. Hopefully these towers are upgradable and phones compatible so they don't have to do this process again in 3 years with some other technology.