Ok here goes nothing...here is my first attempt to make something somewhat decent:
Top Screen: Application drawer (scrollable)
Left Screen: Communications screen with three different states, contacts, calls, and sms (scrollable also, had to blur my contacts and stuff for privacy)
Main Home Screen: Daily agenda with shortcuts, and Twitter
Right Home Screen: Calendar and Power Control
Bottom Screen: Music and shortcuts to settings
I used was Sweeter Home 2 public Beta, and widgets/apps I already had.
Performance wise, I'm still getting the occational Force Close. The only added additional memory load I see is just 3mb for Sweeter Home and 2mb for Slacker radio widget. I was surprised how low Sweeter Home memory load is. I didn't use any Pictures for my customization btw, so that might have helped with the memory load.