My Juice Defender settings are pretty basic - tho I have Ultimate I am mostly on a plain Balanced profile.
There do appear to be some sleep mode issues on this ROM that may affect some more than others...
I know alot of mine are from crap coverage in my apartment complex. Does Denver the the worst cell phone coverage of every city or what? Went from tmobile to verizon and though it's much improved it still sucks compared to Phoenix, Seattle, and San Francisco.
I can leave my phone unplugged at night and wake up with 40% of cell standby with no signal.
Also, JBird_Vegas recently came out saying for D2 users to stay tuned because new development is about to begin. As a D2 user, and never having a D1, I don't care much for needing the bootloader unlocked.