Strange issue, experienced with both Stock 2.1 and Cyanogen 188.8.131.52. Randomly, all the icons on all 5 home screens disappear, including the widgets. Usually, the app drawer still works. However, the only way to get the icons and widgets back is to reboot the phone, and they'll usually vanish again before too long. Primarily, I was using the stock Home screen under CM5062 before the Helix Launchers and Launcher 2 were too laggy. In order to trouble shoot this, I flashed a different launcher, called ADW Launcher, which I rather like. However, the same issue reoccurred, requiring a reboot.
I uninstalled the apps that I've installed the past few days since this started occurring frequently, Mint, UPS, and State Farm Pocket Agent. However, it still happens.
Any ideas? I'd rather not do a full /data & /cache wipe until CM 5.0.7.x. When I flashed the current install of 184.108.40.206, I did a full wipe and format before installing, so it was clean. That was a day or so after 220.127.116.11 was released.