My setup is still a work-in-progress but here is where I am:
My main screen (running a Hero themed GDE). Beautiful Widgets is running the Charcoal HTC Sense skin.
I access most of my apps through this screen. All of the B&W folders / icons shown here and on my main screen were all created using FolderOrganizer.
Icons are curtesy of the Gloss Suite Icon Pack available in the market. I need to figure out how to make more of them with the same look.
I think of this as my "system status" screen.
I have two more but ATM they just have random widgets on them and are nowhere near where I'd like them to be so I didn't even bother screen capping them.