I have two email accounts i use on my Moto Droid. my Gmail and an email account from my work domain. on my desktop i can pick which email address to send from and if i hit the reply button on any email it will just send it. my problem is if i try to respond to an email on my phone from my work account it will not go thought the email get just seats in the out box, I have my work email forward to my gmail account, if that helps.