I used Palm smartphones for years, acutally starting with Handspring, whcih was bought by Palm. My most recent one was a Treo 755P. I knew I would have some adjustments to make when moving to the Droid, with a new and different OS and unfamiliar apps.
I have been happily surprised at the ease with which I have been able to make the switch... certainly more a credit to Android and the Droid than to me! I had become acustomed to my cranky Treo resetting, hiccupping and lagging; the difference is amazing! The Droid actually seems to enjoy its job - a very nice change!
There are a couple of apps I really miss: Dakebk, SplashID, some card games... but overall I really like the installed apps and Oh My! That Market... with all those free goodies!
Before switching I synched everything to Google (contacts, calendar, docs), so the move to the Droid was so clean and simple... no evil USB synching with Outlook!
The learning curve has been much less - and the enjoyment has been much greater - than I expected.
How is your transition from Palm going?